Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone.
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Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone.
An analysis of the factors that influence the increase in plasma immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) concentration in chronic renal failure showed that: (a) the increase correlated with the increase in serum creatinine concentrations; (b) beta-MSH was not cleared from the plasma by haemodialysis; (c) beta-MSH concentrations increased with length of time on dialysis and...
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Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...
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occur with some anticancer agents such as cyclophosphamide (Shah et al., 1975), 5-FU and nitrogen mustard (Moore and Meiselbaugh, 1975), and also with exposure to x-rays (Sutton, 1952; Inalshingh, 1972). Priestman and James (1975) reported 3 cases in which nail changes were possibly due to doxorubicin. They speculated that this drug has a selective hormone-suppressive action which might allow a...
متن کاملPlasma α-melanocyte stimulating hormone predicts outcome in ischemic stroke.
BACKGROUND AND PURPOSE α-Melanocyte stimulating hormone (α-MSH) is an endogenously produced neuropeptide derived from the same precursor as adrenocorticotropic hormone. α-MSH has profound immunomodulatory properties and may also be neuroprotective. Nothing is known about α-MSH and changes in its plasma concentrations in patients with acute ischemic stroke. METHODS In this prospective observat...
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Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on alpha-melanocyte-stimulating hormone (alpha-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutati...
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.6014.874